Spongistatin patents
Web1 Sep 2010 · Spongistatin 1 was applied in an orthotopic in vivo model of human pancreatic cancer. Spongistatin 1 significantly reduced tumor growth, which correlates with a strong apoptosis induction (DNA-fragmentation) and long-term effects on clonogenic survival of pancreatic tumor cells (L3.6pl) in vitro. WebFor example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms.
Spongistatin patents
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WebAn efficient, step-economical, and scalable synthesis of a diene-bearing AB spiroketal fragment of spongistatin 1, and a demonstration of its efficient coupling to an aldehyde derived from silylformylation of a homopropargyl alcohol to produce the entire complex C(13)–C(17) linker region are described. The scalability of the synthesis of the AB …
Web1 Nov 2013 · Endostatin is a 20 kDa C-terminal fragment of type XVIII collagen (O’Reilly et al., 1997), a component of the basement membrane binds to the α5β1/αvβ3 integrin. It is the major fibronectin receptor for endothelial cells (Rehn et al., 2001, Wickström et al., 2002) and may block endothelial cell focal adhesions ( Wickström et al., 2002 ). WebCONSTITUTION: Spongistatin 1 represented by formula having properties as follows: Colorless amorphous powder; melting point: 161 to 162°C; specific rotation: [α]D 22 …
WebSpongistatin 1 inhibited angiogenesis at nanomolar concentrations (IC 50: cytotoxicity> 50 nM, proliferation 100 pM, migration 1.0 nM, tube formation 1.0 nM, chemotaxis 1.0 nM, aortic ring sprouting 500 pM, neovascularization in vivo 10 µg/kg). Further, a kinome array and validating data showed that spongistatin 1 inhibits the phosphorylation activity of … Web602282. 标题: Total synthesis of altohyrtin A (spongistatin 1): Part 1. 作者: Guo, J.; et al. 来源: Angew Chem. Int Ed Engl 1998,37 (1-2),187. 合成路线图解说明: Synthesis of intermediate (VII): The condensation of epoxide (I) with vinyl lithium (II) by means of CuCN gives the allylic alcohol (III), which is epoxidated to epoxide (IV).
WebA black Spongia sp. in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancer) growth inhibitors named spongistatin 2 and spongistatin 3.A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named …
WebFor example, spongistatin 1 (altohyrtin A) is among the most potent compounds tested against a distinctive subset of highly chemoresistant tumour types. While discodermolide and laulimalide share the same microtubule-stabilising mechanism as the anticancer drug Taxol™, they retain antimitotic potency against Taxol-resistant cancer cells. ... arti pita merahWebThe design, synthesis, and biological evaluation of two diminutive forms of (+)-spongistatin 1, in conjunction with the development of a potentially general design strategy to simplify highly flexible macrocyclic molecules while maintaining biological activity, have been achieved. Examination of the solution conformations of (+)-spongistatin 1 revealed a … bandhavgarh national park madhya pradeshWebSpongistatin 1, a macrocyclic lactone from the marine sponge Hyrtios erecta, has broad-spectrum antifungal activity.Since this compound is a potent antimicrotubule agent in mammalian cells, we examined its effects on the filamentous fungus Aspergillus nidulans to determine if its antifungal effects are due to antimicrotubule activity. At 25 μg/ml (twice … arti pisau bermata duaWeb19 Jan 1993 · Patent number: 5393897 Abstract: A Southwest Indian Ocean marine sponge Spirastrella spinispirulifera (bri colored reds and purples) has been found to contain new … arti pitch dalam musikWebspongistatin acid active ingredient doublet methanol Prior art date 1993-07-02 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not … bandhavgarh national park safari packagesWebThe highly cytotoxic, sponge-derived, antimitotic macrolide polyether spongistatin 1 has been previously shown to inhibit microtubule assembly, the binding of vinblastine and … arti pisah hartaWebAn advanced ABCD fragment (see picture) constructed on the way to the total synthesis of the potent antitumor agent (+)‐spongistatin 2 has also been used in a formal total synthesis of (+)‐spongistatin 1. In both cases the critical step was an acid‐mediated epimerization in the presence of Ca 2+ ions to stabilize the axial–equitorial CD spiroketal. arti pitch dalam baut