Lxrα-cyp7a1
Web30 sept. 2024 · CYP7A1 is essential for liver bile acid synthesis. Lactobacillus can regulate CYP7A1 expression through FXR and LXRα pathways. At the same time, lactobacillus regulates genes encoding cholesterol biosynthetic enzyme, including HMGCR, and LDL-R through SREBP to change the synthesis and uptake of cholesterol in the liver. Web10 ian. 2024 · The major bioactive flavonoid isorhamnetin (ISOR) also increased the protein expression of PPAR-γ, LXRα and CYP7A1. Conclusion: SF might promote cholesterol …
Lxrα-cyp7a1
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Web7 feb. 2015 · lxrα 通过激活 cyp7a1 转录来控制这种级联过 程。通过对lxrα 缺失鼠的分析为这一过程提供了 生理学证据，该种鼠在对胆固醇反应过程中不能上 调cyp7a1 表达，结果肝脏胆固醇快速累积达到毒 性水平。 Web10 iul. 2024 · CYP7A1 is induced by the transcription factors LRH1 and LXRα . However, the LXRα response element is not conserved in the human CYP7A1 . The bile acids interact with the binding domain of FXR that subsequently activates its target genes, such as SHP, which inhibit CYP7A1 expression by binding to LRH1 and LXRα [49, 55].
Webhon p.1 [100%] 343 名古屋市立大学大学院薬学研究科分子生物薬学分野 （〒467 8603 名古屋市瑞穂区田辺通3 1） e-mail: p052715＠phar.nagoya-cu.ac.jp http://manu43.magtech.com.cn/Jwk_sygzb/CN/10.3969/j.issn.1672-5069.2024.02.010
WebMaternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny Journal of ... (LDLR) and cholesterol-7alpha hydroxylase (CYP7A1) were decreased in males from fructose-supplemented rats. In contrast, female progeny of fructose-fed mothers did exhibit a clear hypocholesterolemia, … Web28 oct. 2024 · Liver X receptor α (LXRα) LXRα cannot bind to the human CYP7A1 promoter due to an alteration of the DR4 motif in the BARE-I sequence. Therefore, in humans LXRα does not play a role in the regulation of CYP7A1 gene expression. Unlike in humans, LXRα can directly bind to the Cyp7a1 promoter to upregulate expression.
Web5 apr. 2024 · CYP7A1 expression was repressed in the QUE group, CGA and GEN increased CYP7A1 expression, and no change was noted in the CRO group. The role for QUE in suppressing LXRα gene expression and modulating lipid accumulation has previously been described in Huh7 cells .
Web1 apr. 2003 · Although it was reported that the expression of human CYP7a1, in contrast to rat CYP7a1, is not stimulated by LXRα [47], CYP7a1 and LXRα expressions in HepG2 … textify 1.8.3 汉化版Web27 nov. 2024 · Additionally, Cyp7a1 knockout mice expressing human Cyp7a1 exhibit different responses to altered diets than wild-type counterparts . This discrepancy is likely due to the lack of an LXRα binding sequence in the promoter region of the human gene . BA composition can, therefore, be experimentally manipulated highlighting the potential ... textiforWebる．そこで，LXRαにより同様に調節を受けるsterol regulatory element binding protein (SREBP)-1c，fatty acid synthase (FAS) および胆汁酸生合成の律速酵素で あるcholesterol 7α-hydroxylase (CYP7A1) のmRNA発 現量を測定した．FASmRNAはCAS群に比較し，SPI swr 455 trainsWeb26 apr. 2002 · CYP7A1 plays an important role in the regulation of bile acid biosynthesis and cholesterol homeostasis. The oxysterol receptor, LXRα, stimulates whereas the bile acid … swr4 baden-württemberg live radioWeb“胆固醇增高患者的饮食调理”出自《中国民间疗法》期刊2010年第4期文献，主题关键词涉及有等。钛学术提供该文献下载服务。 swr4 audiothekWebLipid efflux mechanisms, relation to disease and potential therapeutic aspects swr4 emailWebDespite advances in healthcare, cardiovascular disease (CVD) remains the leading cause of death in the United States. Elevated levels of plasma cholesterol are highly predictive of CVD and stroke and are the principal driver of atherosclerosis.Unfortunately, current cholesterol lowering agents, such as statins, are not known to reverse atherosclerotic … textify digitals private limited